There's no doubt for me that these are more thoughtfully considered, higher quality product than a typical one-a-day - I ran out briefly and switched back, and I'm pretty sure felt the difference. I sought them out for the more bio-available methyl-folate (instead of folic acid). Since I'm taking a lot of supplements right now I'm happy that I can get most of them Canadian-made through CanPrev. Taking Can-prev vitamin D, Alpha Lipoic and N-Acetyl L-Cysteine too (for fertility related reasons). They are a bigger investment, but I admit I enjoy doing the reading about what I'm choosing, and I appreciate being able to get better pricing on this site than locally. I wish I could get them all locally, but I try to split the difference.